This compound was also examined for mu-opioid receptor activity, and like conolidine, was located to acquire no activity at the site. Making use of the identical paw injection take a look at, several alternatives with larger efficacy had been located that inhibited the initial discomfort reactio

Preliminary scientific tests indicate conolidine may inhibit specific ion channels, minimizing neuronal excitability and restricting agony signals. This system is especially relevant in neuropathic ache, the place abnormal signaling will cause persistent irritation. Also, conolidine appears to a